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Currently Funded Projects

Through careful selection of submitted proposals and focused engagement of experts in disparate areas of science and medicine, the Scleroderma Research Foundation assembles a diverse portfolio of projects. These projects span multiple disciplines and facets of scleroderma research.

2025 Funded Grant Portfolio

SRF Project
Deciphering the female bias of B Cell Tolerance Breach in SSc
Bingfei Yu, PhD
SRF Project
Somatic Mutations in Scleroderma
David Beck, MD, PhD
Shervin Assassi, MD, MS
SRF Project
Epigenetics of Sex Differences in Scleroderma
Paul J. Utz, MD, PhD
Jinwoo Lee, MD, PhD
SRF Project
Spatial Transcriptomics of Skin to Augment Understanding of Cellular Interactions and Disease Propagation in Juvenile Scleroderma
Wei Chen, PhD
Kathryn Torok, MD
SRF Project
Dynamics of XIST RNP Profiles in Scleroderma
Diana Dou, PhD
SRF Project
Alteration of Epigenetic Programs of HSPC Underlies the Chronic Activation of Innate Cells in Systemic Sclerosis
Franck Barrat, PhD
SRF Project
Macrophage-stromal Cell Interactions in Tissue Homeostasis and Fibrosis
Ruslan Medzhitov, PhD
SRF Project
Establishing a Spatially–integrated Transcriptomic, Epigenomic, and Histologic Signature of Fibrosis in Systemic Sclerosis
Michael Longaker, MD, MBA
SRF Project
A Gene Expression Map of Scleroderma
Kathryn Torok, MD
SRF Project
Identifying and Optimizing Care for Mechanistically-driven, Clinically-relevant Scleroderma Subgroups
Ji Soo Kim, MD
Scott Zeger, PhD
Laura Hummers, MD
Ami Shah, MD, MHS
SRF Project
Building a Cellular and Genetic Atlas of Systemic Sclerosis for a Roadmap Toward a Cure
SRF Project
Building a Cellular and Genetic Atlas of Systemic Sclerosis for a Roadmap Toward a Cure
Johann Gudjonsson, MD, PhD
Dinesh Khanna, MD, MSc
SRF Project
Multi-omic Profiling of Interstitial Lung Disease in Systemic Sclerosis
Gerlinde Wernig, MD
SRF Project
DNAse1L3 and the Pathogenesis of Systemic Sclerosis
Kim Simpfendorfer, PhD
SRF Project
Identification of Novel Pathogenic Genes in Juvenile Systemic Sclerosis
Kathryn Torok, MD
SRF Project
Cellular Profiling of Scleroderma and Connective Tissue Disease-Associated Interstitial Lung Diseases
Paul Wolters, MD
SRF Project
Cell Surface GlycoRNAs in Autoimmunity
SRF Project
Identifying Novel Antibody Reactivities to Explain, Define, and Predict Subphenotypes of Scleroderma
Aaron Bodansky, MD
Joe Derisi, PhD
SRF Project
Cell Surface GlycoRNAs in Autoimmunity
Ryan Flynn, MD, PhD

SRF and SCTC Jointly Funded Projects