Skip to main content

Testing and Diagnosis

How Is Scleroderma Diagnosed?

There is no single test for scleroderma. Instead, doctors diagnose the disease by combining your symptoms, physical examination, blood tests, and imaging studies.

Physical Examination

Your doctor may look for:

These findings help identify systemic sclerosis and distinguish it from other conditions.

Blood Tests

Blood tests can help confirm the diagnosis and provide information about the type of scleroderma you have.
Common antibodies include:

  • Anticentromere
  • Anti-Scl-70
  • RNA Polymerase III

These antibodies may also help predict which body systems should be monitored.

Imaging and Screening Tests

Because scleroderma can affect internal organs before symptoms appear, your doctor may recommend these tests, even if you feel well:

  • High-resolution CT scan
  • Pulmonary function tests
  • Echocardiogram
  • Electrocardiogram (EKG)

These tests help identify lung and heart involvement early.

Why Early Detection Matters

Early screening allows doctors to detect complications such as interstitial lung disease and pulmonary hypertension before symptoms develop—making early treatment possible and helping put you in a stronger position to manage your health.