Current Funded Projects
Autoantibodies Targeting the Telomerase Complex in Scleroderma
Johns Hopkins University School of Medicine
Brittany Adler, MD Instructor in Medicine in the Division of Rheumatology
Project description coming soon.
Role of CXCL4-induced TLR9 Defects Promote the Production of Autoreactive B-cells in Scleroderma
Hospital for Special Surgery
Yale School of Medicine
Franck Barrat, PhD Senior Scientist
Eric Meffre, PhD Associate Professor of Immunobiology and Medicine
Cancer Detection Strategies in Patients with Scleroderma
Johns Hopkins University School of Medicine
Livia Casciola-Rosen, PhD Professor of Medicine
Ami Shah, MD, MHS Associate Professor of Medicine
Gene Regulatory Mechanisms in Scleroderma
Stanford University School of Medicine
Howard Hughes Medical Institute
Howard Chang, MD, PhD Virginia and D. K. Ludwig Professor of Cancer and Genomics and of Genetics, Director, NIH Center of Excellence in Genomic Science; Investigator, Howard Hughes Medical Institute; Director, Center for Personal Dynamic Regulomes, Professor of Dermatology and of Genetics
Epigenetics of Sex Differences in Scleroderma
Stanford University School of Medicine
Howard Hughes Medical Institute
Howard Chang, MD, PhD Virginia and D. K. Ludwig Professor of Cancer and Genomics and of Genetics, Director, NIH Center of Excellence in Genomic Science; Investigator, Howard Hughes Medical Institute; Director, Center for Personal Dynamic Regulomes, Professor of Dermatology and of Genetics
Scleroderma Twin Study
Stanford University School of Medicine
Howard Chang, MD, PhD Virginia and D. K. Ludwig Professor of Cancer and Genomics and of Genetics, Director, NIH Center of Excellence in Genomic Science; Investigator, Howard Hughes Medical Institute
Establishing a Spatially–Integrated Transcriptomic, Epigenomic, and Histologic Signature of Fibrosis in Systemic Sclerosis
Stanford University School of Medicine
Michael Longaker, MD Deane P. and Louise Mitchell Professor in the School of Medicine and Professor, by courtesy, of Materials Science and Engineering
Howard Chang, MD, PhD Virginia and D. K. Ludwig Professor of Cancer and Genomics and of Genetics, Director, NIH Center of Excellence in Genomic Science; Investigator, Howard Hughes Medical Institute
Stanford Scleroderma Center of Excellence
Stanford University School of Medicine
Lorinda Chung, MD, MS Associate Professor of Medicine
Northern California Scleroderma Research Consortium
Stanford University School of Medicine
University of California, San Francisco
Lorinda Chung, MD, MS Associate Professor of Medicine
Paul Wolters, MD Professor of Medicine
POL3-specific CD8+ T Cells as the Link Between Scleroderma and Anti-tumor Immune Responses
Johns Hopkins University School of Medicine
Erika Darrah, PhD Assistant Professor of Medicine
Eleni Tiniakou, MD Assistant Professor of Medicine
Naturally Presented Topoisomerase Epitopes in Scleroderma Patients with HLA-DPB1*13:01
Johns Hopkins University School of Medicine
Erika Darrah, PhD Assistant Professor of Medicine
Eleni Tiniakou, MD Assistant Professor of Medicine
Assessment of the Complement Cascade as a Novel Biomarker, Genetic Risk Factor, and Treatment Target for Scleroderma-Associated Pulmonary Arterial Hypertension
University of Rochester School of Medicine and Dentistry
Benjamin Korman, MD Assistant Professor of Medicine
Measuring and Objectively Characterizing Patterns of Gastrointestinal Dysmotility in Scleroderma
Johns Hopkins University School of Medicine
Zsuzsanna McMahan, MD Assistant Professor of Medicine
Macrophage-Stromal Cell Interactions in Tissue Homeostasis and Fibrosis
Yale School of Medicine
Howard Hughes Medical Institute
Ruslan Medzhitov, PhD Sterling Professor of Immunobiology; Investigator, Howard Hughes Medical Institute
Understanding the Biological Basis of Enteric Nervous System Dysfunction in Systemic Sclerosis
Johns Hopkins University School of Medicine
Jay Pasricha, MD Director of the Johns Hopkins Center for Neurogastroenterology; Professor of Medicine
Subhash Kulkarni, MS, PhD Assistant Professor of Medicine
Project description coming soon.
Identification of Novel Pathogenic Genes in Juvenile Systemic Sclerosis
Pittsburgh Children’s Hospital
National Human Genome Research Institute
Kathryn Torok, MD Associate Professor of Medicine
Dan Kastner, MD, PhD Scientific Director of the Intramural Program at the National Human Genome Research Institute
Elaine Remmers, PhD Associate Investigator, Inflammatory Disease Section
Immune Checkpoint Inhibitors as Antifibrotic Therapy for Scleroderma
Stanford University School of Medicine
Gerlinde Wernig, MD Assistant Professor of Pathology
Molecular Subsets, Integrative Genomics and Tissue Models of Scleroderma
Geisel School of Medicine at Dartmouth
Michael L. Whitfield, PhD Chair and Professor of Biomedical Data Science; Professor of Molecular and Systems
Johns Hopkins Scleroderma Center of Excellence
Johns Hopkins University School of Medicine
Fredrick Wigley, MD Director, the Johns Hopkins Scleroderma Center and Associate Director, Division of Rheumatology; Martha McCrory Professor of Medicine
Laura Hummers, MD, MPH Clinical Director, Division of Rheumatology, Associate Professor of Medicine
Ami Shah, MD, MHS Associate Professor of Medicine
Genome Research in African American Scleroderma Patients (The GRASP Project)
Cedars-Sinai
Johns Hopkins University School of Medicine
National Human Genome Research Institute
National Institute of Arthritis & Musculoskeletal Disease
Fredrick Wigley, MD Director, the Johns Hopkins Scleroderma Center and Associate Director, Division of Rheumatology
Francesco Boin, MD Director, Rheumatology Division, Kao Autoimmunity Institute
In collaboration with
Dan Kastner, MD, PhD Scientific Director of the Intramural Program at the National Human Genome Research Institute
Pravitt Gourh, MD Head, Scleroderma Genomics and Health Disparities Unit
Adjunct Investigator, National Institute on Minority Health and Health Disparities (NIMHD)
Telomere Length and Interstitial Lung Disease in Systemic Sclerosis
University of California, San Francisco
Paul Wolters, MD Professor of Medicine
Project description coming soon.
Systemic Sclerosis Lung Disease Trajectory Modeling Project
Johns Hopkins University School of Medicine
Scott Zeger, PhD Professor of Biostatistics
Ami Shah, MD, MHS Associate Professor of Medicine
Antony Rosen, MD Vice Dean for Research; Mary Betty Stevens Professor of Medicine
Laura Hummers, MD, MPH Clinical Director, Division of Rheumatology, Associate Professor of Medicine
Fredrick Wigley, MD Director, the Johns Hopkins Scleroderma Center and Associate Director, Division of Rheumatology; Martha McCrory Professor of Medicine
Multi-omic Profiling of Interstitial Lung Disease in Systemic Sclerosis
Paul Wolters, MD Professor of Medicine, UC San Francisco
Gerlinde Wernig, MD Assistant Professor of Pathology, Stanford University
Howard Chang, MD, PhD Virginia and D. K. Ludwig Professor of Cancer and Genomics and of Genetics, Director, NIH Center of Excellence in Genomic Science; Investigator, Howard Hughes Medical Institute