Funded Projects

Through careful selection of submitted proposals and focused engagement of experts in disparate areas of science and medicine, the Scleroderma Research Foundation assembles a diverse portfolio of projects. These projects span multiple disciplines and facets of scleroderma research.

2024 Portfolio

Funded Grants

Regulation of Inflammation and IFN-I response in the Fibrotic Skin Environment

Franck Barrat, PhD
Hospital for Special Surgery — Senior Scientist

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Cell Surface GlycoRNAs in Autoimmunity

Ryan Flynn, MD, PhD
Boston Children’s Hospital —Assistant Professor
Harvard University — Assistant Professor, Stem Cell and Regenerative Biology

with
Elana J. Bernstein, MD, MSc
Columbia University — Associate Professor of Medicine; Director, Columbia University/New York-Presbyterian Hospital Scleroderma Program

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Building a Cellular and Genetic Atlas of Systemic Sclerosis for a Roadmap Toward a Cure

Dinesh Khanna, MD, MSc
University of Michigan — Frederick G L Huetwell Professor of Rheumatology and Professor of Internal Medicine
Johann Gudjonsson, MD, PhD
University of Michigan — Arthur C. Curtis Professor of Molecular Skin Immunology and the Frances and Kenneth Eisenberg Emerging Scholar of the Taubman Medical Research Institute

Establishing a Spatially–integrated Transcriptomic, Epigenomic, and Histologic Signature of Fibrosis in Systemic Sclerosis

Michael Longaker, MD
Stanford University School of Medicine – Deane P. and Louise Mitchell Professor in the School of Medicine and Professor, by courtesy, of Materials Science and Engineering

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Examining Mechanisms of Autonomic Nervous System Dysfunction and GI Disease in Scleroderma

Zsuzsanna McMahan, MD of the UTHealth Houston McGovern School of Medicine
Gabsang Lee of the Johns Hopkins University School of Medicine

Macrophage-stromal Cell Interactions in Tissue Homeostasis and Fibrosis

Ruslan Medzhitov, PhD
Yale School of Medicine — Sterling Professor of Immunobiology
Howard Hughes Medical Institute — Investigator

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Identifying and Optimizing Care for Mechanistically-driven, Clinically-relevant Scleroderma Subgroups

Ami Shah, MD, MHS
Johns Hopkins University School of Medicine – Associate Professor of Medicine
Scott Zeger, PhD
Johns Hopkins University School of Medicine — Professor of Biostatistics
Laura Hummers, MD of the Johns Hopkins University School of Medicine
Ji Soo Kim, PhD of the Johns Hopkins University School of Medicine

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Spatial Transcriptomics of Skin to Augment Understanding of Cellular Interactions and Disease Propagation in Juvenile Scleroderma

Kathryn Torok, MD 
Pittsburgh Children’s Hospital — Associate Professor of Medicine
Wei Chen, PhD
University of Pittsburgh — Professor of Pediatrics, Biostatistics, and Human Genetics

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Identification of Novel Pathogenic Genes in Juvenile Systemic Sclerosis

Kathryn Torok, MD 
Pittsburgh Children’s Hospital — Associate Professor of Medicine

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Gene Regulatory Mechanisms in Scleroderma

Paul J. Utz, MD, PhD
Stanford University School of Medicine — Professor of Medicine (Immunology and Rheumatology)

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Epigenetics of Sex Differences in Scleroderma

Paul J. Utz, MD, PhD
Stanford University School of Medicine — Professor of Medicine (Immunology and Rheumatology)

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Scleroderma Twin Study

Paul J. Utz, MD, PhD
Stanford University School of Medicine — Professor of Medicine (Immunology and Rheumatology)

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A Gene Expression Map of Scleroderma

Michael L. Whitfield, PhD
Geisel School of Medicine at Dartmouth — Chair and Professor of Biomedical Data Science; Professor of Molecular and Systems

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Multi-omic Profiling of Interstitial Lung Disease in Systemic Sclerosis

Paul Wolters, MD
University of California, San Francisco — Professor of Medicine
Gerlinde Wernig, MD
Stanford University — Assistant Professor of Pathology

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Identifying Unique Molecular Profiles of Subtypes of Scleroderma-associated ILD

Paul Wolters, MD
University of California, San Francisco — Professor of Medicine

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Deciphering the female bias of B Cell Tolerance Breach in SSc

Bingfei Yu, PhD
University of Southern California — Assistant Professor of Medicine

with
Elizabeth Volkmann, MD, MS
University of California, Los Angeles — Director of the UCLA Scleroderma Program, Co-Director of the UCLA Connective Tissue Disease-Related Interstitial Lung Disease (CTD-ILD) Program

On-going Projects

Characterization of Somatic Mutations in Scleroderma

David Beck, MD, PhD of New York University
Shervin Assassi, MD, MS of the UTHealth Houston McGovern School of Medicine

Scleroderma Research Foundation and Scleroderma Clinical Trials Consortium (SCTC) Jointly Funded Projects

CRISTAL: Developing the Combined Response Index for Scleroderma Trials Assessing Limited Cutaneous Systemic Sclerosis

Dinesh Khanna, MD, MSc of the University of Michigan and Alain Lescoat, MD of the University Hospital of Rennes

Previously Funded Projects

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