Through careful selection of submitted proposals and focused engagement of experts in disparate areas of science and medicine, the Scleroderma Research Foundation assembles a diverse portfolio of projects. These projects span multiple disciplines and facets of scleroderma research.
Regulation of Inflammation and IFN-I response in the Fibrotic Skin Environment
Franck Barrat, PhD
Hospital for Special Surgery — Senior Scientist
Cell Surface GlycoRNAs in Autoimmunity
Ryan Flynn, MD, PhD
Boston Children’s Hospital —Assistant Professor
Harvard University — Assistant Professor, Stem Cell and Regenerative Biology
with
Elana J. Bernstein, MD, MSc
Columbia University — Associate Professor of Medicine; Director, Columbia University/New York-Presbyterian Hospital Scleroderma Program
Building a Cellular and Genetic Atlas of Systemic Sclerosis for a Roadmap Toward a Cure
Dinesh Khanna, MD, MSc
University of Michigan — Frederick G L Huetwell Professor of Rheumatology and Professor of Internal Medicine
Johann Gudjonsson, MD, PhD
University of Michigan — Arthur C. Curtis Professor of Molecular Skin Immunology and the Frances and Kenneth Eisenberg Emerging Scholar of the Taubman Medical Research Institute
Establishing a Spatially–integrated Transcriptomic, Epigenomic, and Histologic Signature of Fibrosis in Systemic Sclerosis
Michael Longaker, MD
Stanford University School of Medicine – Deane P. and Louise Mitchell Professor in the School of Medicine and Professor, by courtesy, of Materials Science and Engineering
Examining Mechanisms of Autonomic Nervous System Dysfunction and GI Disease in Scleroderma
Zsuzsanna McMahan, MD of the UTHealth Houston McGovern School of Medicine
Gabsang Lee of the Johns Hopkins University School of Medicine
Macrophage-stromal Cell Interactions in Tissue Homeostasis and Fibrosis
Ruslan Medzhitov, PhD
Yale School of Medicine — Sterling Professor of Immunobiology
Howard Hughes Medical Institute — Investigator
Identifying and Optimizing Care for Mechanistically-driven, Clinically-relevant Scleroderma Subgroups
Ami Shah, MD, MHS
Johns Hopkins University School of Medicine – Associate Professor of Medicine
Scott Zeger, PhD
Johns Hopkins University School of Medicine — Professor of Biostatistics
Laura Hummers, MD of the Johns Hopkins University School of Medicine
Ji Soo Kim, PhD of the Johns Hopkins University School of Medicine
Spatial Transcriptomics of Skin to Augment Understanding of Cellular Interactions and Disease Propagation in Juvenile Scleroderma
Kathryn Torok, MD
Pittsburgh Children’s Hospital — Associate Professor of Medicine
Wei Chen, PhD
University of Pittsburgh — Professor of Pediatrics, Biostatistics, and Human Genetics
Identification of Novel Pathogenic Genes in Juvenile Systemic Sclerosis
Kathryn Torok, MD
Pittsburgh Children’s Hospital — Associate Professor of Medicine
Gene Regulatory Mechanisms in Scleroderma
Paul J. Utz, MD, PhD
Stanford University School of Medicine — Professor of Medicine (Immunology and Rheumatology)
Epigenetics of Sex Differences in Scleroderma
Paul J. Utz, MD, PhD
Stanford University School of Medicine — Professor of Medicine (Immunology and Rheumatology)
Scleroderma Twin Study
Paul J. Utz, MD, PhD
Stanford University School of Medicine — Professor of Medicine (Immunology and Rheumatology)
A Gene Expression Map of Scleroderma
Michael L. Whitfield, PhD
Geisel School of Medicine at Dartmouth — Chair and Professor of Biomedical Data Science; Professor of Molecular and Systems
Multi-omic Profiling of Interstitial Lung Disease in Systemic Sclerosis
Paul Wolters, MD
University of California, San Francisco — Professor of Medicine
Gerlinde Wernig, MD
Stanford University — Assistant Professor of Pathology
Identifying Unique Molecular Profiles of Subtypes of Scleroderma-associated ILD
Paul Wolters, MD
University of California, San Francisco — Professor of Medicine
Deciphering the female bias of B Cell Tolerance Breach in SSc
Bingfei Yu, PhD
University of Southern California — Assistant Professor of Medicine
with
Elizabeth Volkmann, MD, MS
University of California, Los Angeles — Director of the UCLA Scleroderma Program, Co-Director of the UCLA Connective Tissue Disease-Related Interstitial Lung Disease (CTD-ILD) Program
Characterization of Somatic Mutations in Scleroderma
David Beck, MD, PhD of New York University
Shervin Assassi, MD, MS of the UTHealth Houston McGovern School of Medicine
CRISTAL: Developing the Combined Response Index for Scleroderma Trials Assessing Limited Cutaneous Systemic Sclerosis
Dinesh Khanna, MD, MSc of the University of Michigan and Alain Lescoat, MD of the University Hospital of Rennes