SRF researchers Michael Longaker, MD, MBA, and Howard Chang, MD, PhD, both of Stanford University, recently published a paper in PNAS on their newly-developed integrated spatial multi-omic analysis platform, which they used to understand how the numerous fibroblast populations present in skin choreograph repair of a wound. The SRF is funding the Longaker and Chang research groups to further develop their cutting-edge technology and apply it to understanding how altered fibroblast function leads to fibrosis in scleroderma.
“Drs. Longaker and Chang’s work is a huge advance in our ability to investigate and understand fibroblast biology and we believe it will lead to significant advances in fibrosis research,” explains SRF Board Member Deann Wright.
Photo shows “color-coded” fibroblast populations moving toward the center of a wound.
Citation: “Integrated spatial multiomics reveals fibroblast fate during tissue repair” Foster, et. al., PNAS 2021.
